Tildipirosin
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Tildipirosin
Tildipirosin yog ib yam tshiab ntawm semi-synthetic 16-membered nplhaib macrolide tshuaj tua kab mob rau tsiaj, uas yog ib tug derivative ntawm tylosin.
Pharmacological kev ua
Cov nyhuv antibacterial ntawm Tildipirosin zoo ib yam li tylosin, thiab nws muaj zog inhibitory nyhuv ntawm cov kab mob Gram-positive thiab qee cov kab mob Gram-negative.Cov tshuaj tua kab mob ntawm Tildipirosin yog tib yam li ntawm macrolides.Nws tuaj yeem ua ke nrog 50S subunit ntawm ribosome ntawm cov kab mob rhiab heev los tiv thaiv kev sib txuas ntawm riboprotein peptide chains, yog li cuam tshuam rau cov synthesis ntawm cov kab mob proteins.Kev sib cuam tshuam ntawm ob qho khoom siv piperidine tshwj xeeb rau Tildipirosin sib txawv cov txheej txheem ntawm kev ua ntawm cov tshuaj no los ntawm tylosin thiab tilmicosin, qhov twg 20-piperidine raug coj mus rau hauv lumen los cuam tshuam nrog kev loj hlob ntawm nascent peptides.
Vim tias tediroxine muaj 3 pawg amino hauv paus, nws tuaj yeem tsim cov ntawv them nqi sib txawv raws li pH sib txawv.Tus nqi ntawm tus nqi yog qhov tseem ceeb los rhuav tshem cov solubility ntawm cov kab mob lipids thiab nkag mus rau sab nraud ntawm cov kab mob Gram-tsis zoo, yog li cov bacteriostatic kev ua ntawm Tildipirosin hauv vitro cuam tshuam los ntawm pH.Nyob rau hauv acidic tej yam kev mob, cov amino pawg yog protonated, uas ua rau ib tug txo nyob rau hauv lub antibacterial kev ua si ntawm tediroxine, thaum nyob rau hauv alkaline tej yam kev mob, nws muaj zog antibacterial kev ua si.
Macrolides inhibit qhov tso tawm ntawm proinflammatory cytokines, phospholipase kev ua, thiab leukotriene tso tawm, thiab muaj cov tshuaj tiv thaiv kab mob hauv macrophages thiab neutrophils.Tediroxine txo cov inflammatory mediators uas tsim thaum lub sij hawm tej yam inflammatory los yog kev nyuaj siab teb.
Antibacterial spectrum
Tildipirosin muaj txiaj ntsig zoo rau cov kab mob pathogenic uas ua rau cov kab mob ua pa hauv npua thiab nyuj (xws li Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. thiab lwm yam) cov tshuaj tua kab mob ntawm tilmicosin 2 zaug ntau dua li ntawm 2 zaug. , thiab cov tshuaj tua kab mob tawm tsam plab hnyuv Escherichia coli zoo dua li tylosin thiab tilmicosin.Nws kuj tseem nkag siab rau qee hom kab mob mycoplasma, spirochetes, brucella, thiab lwm yam. Cov kev tshawb fawb tau pom tias tediroxine muaj zog bacteriostatic nyhuv ntawm Haemophilus parasuis thiab Bordetella bronchiseptica dua li florfenicol, tab sis tsis muaj zog bacteriostatic nyhuv ntawm Actinobacillus pleuropneumuloniae thiab Pastinobacillus pleuropneumuloniae.Tildipirosin yog bactericidal rau qee cov kab mob (xws li Haemophilus parasuis thiab Actinobacillus pleuropneumoniae), thaum nws yog bacteriostatic rau qee cov kab mob (xws li Pasteurella multocida).Rau cov kab mob hauv plab, nrog qhov txo qis ntawm pH tus nqi (los ntawm 7.3 txog 6.7), MIC ntawm Tildipirosin nce, piv txwv li, MIC ntawm Tildipirosin tiv thaiv Salmonella Enteritidis thiab Escherichia coli tuaj yeem nce los ntawm 2 ~ 8ug / m txog 64 ~ 256ug / mL. .Yog li, cov txiaj ntsig ntawm pH hloov hauv vivo yuav tsum tau txiav txim siab thaum ua qhov kev sim tshuaj tua kab mob hauv vivo ntawm Tildipirosin.Tsis tas li ntawd, MIC ntawm Tildipirosin tiv thaiv cov kab mob xws li Pasteurella multocida yog 0.5ug / mL hauv cov ntshav, uas yog 0.25 npaug qis dua li hauv vitro, uas tej zaum yuav cuam tshuam rau cov nyhuv hauv cov ntshav.
Enterococcus-Streptococcus nyob rau hauv nyuj nyuj yog heev resistant rau tediroxine.Tildipirosin yog insensitive rau Pasteurella multocida thiab Mannheimia haemolyticus nqa mutant noob.Ib yam li ntawd, genetic mutated hom M. bovis yog resistant rau macrolide tshuaj tua kab mob xws li Tildipirosin.Qee hom kab mob Haemophilus parasuis kuj tau pom tias muaj peev xwm tiv taus tediroxine.Mycoplasma bovis tuaj yeem tau txais cov tshuaj tiv thaiv Tildipirosin sai sai, tab sis vim qhov kev loj hlob qeeb ntawm Mycoplasma, hauv vitro tshuaj tiv thaiv kab mob yuav ncua kev kho mob.Cov kev tshawb fawb tau pom tias domain II (nucleotide 748) thiab domain V (Kev hloov pauv hauv nucleotides 2059 thiab 2060) cuam tshuam nrog kev tiv thaiv ntau ntxiv rau macrolides.Yog li ntawd, qhov susceptibility ntawm M. bovis rau cov tshuaj macrolide tuaj yeem tau sai sai los ntawm kev sim molecular ntawm qhov kev hloov pauv no.
Cov ntsiab lus
≥ 98%
Specification
Tuam txhab txheem
Hebei Veyong kws tshuaj Co., Ltd, tau tsim nyob rau hauv 2002, nyob rau hauv Shijiazhuang City, Hebei xeev, Tuam Tshoj, ib sab ntawm lub peev Beijing.Nws yog ib lub tuam txhab loj GMP-certified veterinary tshuaj lag luam, nrog R & D, ntau lawm thiab muag khoom ntawm veterinary APIs, npaj, premixed pub thiab pub additives.Raws li Provincial Technical Center, Veyong tau tsim ib qho kev tsim kho tshiab R&D rau cov tshuaj kho tsiaj tshiab, thiab yog lub teb chaws paub txog kev tsim kho tshiab raws li kws kho tsiaj, muaj 65 tus kws tshaj lij.Veyong muaj ob lub hauv paus tsim khoom: Shijiazhuang thiab Ordos, uas lub hauv paus Shijiazhuang npog thaj tsam ntawm 78,706 m2, nrog 13 API khoom suav nrog Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, thiab 11 npaj cov kab ntau lawm suav nrog kev txhaj tshuaj, qhov ncauj tshuaj, , premix, bolus, tshuaj tua kab thiab tshuaj tua kab mob, ects.Veyong muab APIs, ntau tshaj 100 tus kheej-daim ntawv npaj, thiab OEM & ODM kev pabcuam.
Veyong tseem ceeb heev rau kev tswj hwm ntawm EHS (Environment, Health & Safety) system, thiab tau txais daim ntawv pov thawj ISO14001 thiab OHSAS18001.Veyong tau teev nyob rau hauv cov kev lag luam tawm tswv yim tawm tswv yim hauv Hebei Xeev thiab tuaj yeem ua kom cov khoom lag luam tas mus li.
Veyong tau tsim ua tiav kev tswj hwm zoo, tau txais daim ntawv pov thawj ISO9001, Tuam Tshoj GMP daim ntawv pov thawj, Australia APVMA GMP daim ntawv pov thawj, Ethiopia GMP daim ntawv pov thawj, Ivermectin CEP daim ntawv pov thawj, thiab dhau US FDA tshuaj xyuas.Veyong muaj pab pawg tshaj lij ntawm kev sau npe, kev muag khoom thiab kev pabcuam, peb lub tuam txhab tau txais kev cia siab thiab kev txhawb nqa los ntawm ntau tus neeg siv khoom los ntawm cov khoom lag luam zoo, kev muag khoom zoo thiab kev pabcuam tomqab muag, kev tswj xyuas thiab kev tshawb fawb.Veyong tau ua kev koom tes ntev nrog ntau lub tuam txhab kev lag luam tsiaj paub thoob ntiaj teb nrog cov khoom xa tawm mus rau Tebchaws Europe, South America, Middle East, Africa, Asia, thiab lwm yam ntau tshaj 60 lub teb chaws thiab cheeb tsam.
