Tildipirosin
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Tildipirosin
Tildipirosin yog hom tshiab ntawm semi-hluavtaws 16-tswv cuab nplhaib macrolide tshuaj tua kab mob rau cov tsiaj txhu, uas yog ib qho kev sib tw ntawm tylosin.
Pharmacological txiav txim siab
Cov nyhuv antibacterial ntawm Tildipirosin zoo ib yam li ntawm Tylipirosin zoo ib yam li ntawm Tylosin, thiab nws muaj cov kab mob muaj zog loj thiab muaj qee cov kab mob tsis zoo. Cov tshuaj tua kab mob ntawm Tildipirosin yog tib yam li macrolides. Nws tuaj yeem sib txuas nrog 50s submunit ntawm cov kab mob uas rhiab rau kev sib txuas ntawm cov hluavtaws duav, yog li cuam tshuam cov synthestery ntawm cov kab mob protein. Qhov kev sib cuam tshuam ntawm ob lub piperaudine tshwj xeeb rau Tildipirosin sib txawv ntawm cov tshuaj no ntawm cov lumen los cuam tshuam nrog kev loj hlob ntawm cov kev loj hlob ntawm cov kev loj hlob.
Vim tias Tediroxine muaj 3 pab pawg amino yooj yim, nws tuaj yeem tsim cov ntawv sib txawv raws li cov tsiaj sib txawv. Tus nqi ntawm tus nqi yog qhov tseem ceeb ua kom rhuav tshem cov solubility ntawm cov kab mob ntawm cov kab mob ntawm tildipirosin hauv vitro tau cuam tshuam ntau heev los ntawm ph. Nyob rau hauv acidic tej yam kev mob, cov amino pab pawg yog protonated, uas tau ua rau cov kab mob antibacterial ntawm Tediroxine, thaum hauv qab cov xwm txheej Alkaline, nws muaj cov zog tshuaj tua kab mob.
Macrolides inhibit lub zais ntawm propordammatatory kev ua si, thiab leukotriene tso tawm, thiab muaj kev cuam tshuam rau hauv macrophages thiab neurophils. Tedirhoxine txo cov mob sib kho ua rau muaj kev mob siab rau thaum qee qhov kev pom zoo lossis kev ntxhov siab.
Cov tshuaj tua hluav taws
Tildipirosin yog siv tau tawm tsam cov kab mob pathogenic uas ua rau muaj kev ua pa ntawm Tilmicosin yog 2-32 lub sij hawm siab tshaj li ntawm Tilmicosin, Thiab cov kev ua phem rau kev tawm tsam txoj hnyuv Escherichia Coli tau zoo dua li Tylosin thiab Tilmicosin. Nws tseem nkag siab rau qee cov mypsplasma hom, spiroostatic ParasisTation ntawm Actinobacacal effection rau Actinobacacillus paleurella thiab pasteurella multipida. Tildipirosin yog Bactericidal rau qee cov kab mob (xws li Haemophilus Parasisis thiab Actinobacillus pleuroostatic rau qee cov kab mob (xws li pasteurella mulcida). Rau plab hnyuv kab mob, nrog rau qhov tsawg dua ntawm PHICE (los ntawm 7. The MOL ntawm Tildipirosin tau nce ntxiv ntawm 2 ~ 8ug / m rau 64 ~ 256ug / ml. Yog li ntawd, cov nyhuv ntawm pH cov kev hloov pauv ntawm vivo yuav tsum tau txiav txim siab thaum ua rau kev sim Vivo Antibacirosin. Tsis tas li ntawd, lub mic ntawm Tildipirosin tiv thaiv cov kab ke ntawm Sweeurella multipida yog 0.5ug / ml hauv ntshav qab zib, uas muaj feem cuam tshuam nrog cov ntshav ntshav.
Enterococcus-Streptococcus hauv cov mis nyuj uas tsis muaj mis nyuj yog qhov tsis txaus ntseeg Tediroxine. Tildipirosin yog insensitive rau pasteurella multipida thiab Mannheimia Himolyticus nqa cov noob mutant. Ib yam li ntawd, kev sib cav sib ceg ntawm M. Bovis tiv thaiv macrolide tshuaj tua kab mob xws li Tildipirosin. Qee hom kev sib tw ntawm Haemophilus Parasised kuj tau pom tias yog ib txwm tiv taus Tediroxine. MyClasplasma Bovis tuaj yeem nrawm nrawm mus rau Tildipirosin, tab sis vim muaj kev kawm qeeb ntawm mycopasma, hauv cov tshuaj vitro tshuaj muaj kev sib cav tuaj yeem ncua kev kho. Cov kev tshawb fawb tau qhia tias Lomain II (Nucleotide 748) thiab sau V (kev sib hloov hauv Nucleotides 2059) yog txuam nrog kev nce ntxiv rau macyrolides. Yog li ntawd, kev ntxim nyiam ntawm M. Bovis rau cov tshuaj macrolide tuaj yeem nrawm nrawm ntawm cov molecular xeem ntawm qhov kev hloov pauv no.
Zoo siab
≥ 98%
Kev qhia tshwj xeeb
Tuam txhab Tuam Txhab Qauv
Heii Veyong Kws Tshuaj Co., Ltd, tau tsim tsa hauv xyoo 2002, nyob hauv Shijiazhuang nroog, Hebei Xeev, Suav, ib sab ntawm lub peev Beijing. Nws yog ib qho loj GMP-lees paub cov kws kho tsiaj siv tshuaj kho, nrog R & D, ntau lawm thiab kev muag khoom ntawm cov kws kho tsiaj kho mob thiab pub zaub mov noj thiab pub ntxiv. Raws li Pretincial Technical Center, VeYong tau tsim ib qho kev tsim kho tshiab R & D qhov tsim kho tshiab ua haujlwm raws cov kws kho tsiaj tsim kho kom zoo nkauj, muaj 65 tus kws tshaj lij kev ua haujlwm. Veyong muaj ob lub hauv paus ntau lawm: shijiazhuang thiab ordos, thiab 11 aprinomection ecotharate ecothuang, hmoov, premix, bolus, tshuaj tua kab thiab tshuaj tua kab mob, ects. Veyong muab APIs, ntau dua 100 tus kheej npaj, thiab OEM & ODM kev pabcuam.
Veyong txuas qhov tseem ceeb rau kev tswj hwm ntawm EHS (ib puag ncig & kev nyab xeeb) system, thiab tau txais ISO14001 thiab OHSAS18001 daim ntawv pov. Veyong tau teev nyob rau hauv cov tswv yim tawm kev lag luam muaj kev lag luam hauv Hebi xeev thiab tuaj yeem ua kom cov khoom lag luam txuas ntxiv.
Veyong tsim cov txheej txheem tswj hwm zoo, tau txais ISO9001 Daim Ntawv Pov Thawj GMP, Australia GMP Daim Ntawv Pov Thawj, Tebchaws Australia, Tebchaws Asmeskas Kev Tshawb Xyuas FDA. Veyong muaj cov pab pawg tshaj lij ntawm kev sau npe, kev lag luam thiab kev txhawb nqa los ntawm ntau cov khoom lag luam zoo, muaj kev pab cuam ua ntej thiab kev tswj hwm tom qab kev tshawb fawb. Veyong tau ua haujlwm ntev ntev nrog ntau cov khoom lag luam hauv nroog, South America, Tebchaws Asmeskas, thiab lwm yam Ntau tshaj 60 lub tebchaws thiab cheeb tsam.
