250mg Triclabendazole Bolus
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Pharmacological Actions
Pharmacodynamics Triclobendazole belongs rau benzimidazole chav kawm ntawm cov tshuaj, tshwj xeeb tshaj yog siv los tiv thaiv Fasciola hepatica, thiab muaj peev xwm tua cov nyhuv ntawm Fasciola hepatica ntawm ntau lub hnub nyoog.tshuaj fluke.Tom qab cov tshuaj absorbed, nws cuam tshuam nrog microtubule qauv thiab kev ua haujlwm ntawm cov cab, inhibits qhov tso tawm ntawm parasite hydrolytic proteases.Cov nyhuv ntawm triclobendazole rau cov kab mob sib txawv nrog cov concentration, xws li cov neeg laus ntawm qhov tsis tshua muaj siab (1 ~ 3μg / ml)
Cov tshuaj tseem muaj sia nyob rau 24 teev, thiab kev ua haujlwm tau poob qis hauv qhov siab dua (10-25μg / ml) rau 24 teev;lub siab concentration ntawm 25-50μg / ml tag nrho inhibits nws rau 24 teev.Tab sis ntau rhiab heev rau worms.Ntawm 10 μg / ml, tag nrho cov haujlwm 24-teev raug txwv.
Pharmacokinetics
Lub bioavailability ntawm triclobendazole yog siab.Tom qab kev tswj hwm qhov ncauj ntawm 10 mg / kg lub cev qhov hnyav hauv tshis thiab yaj, cov tshuaj ntshav siab tshaj plaws tau mus txog 15 μg / ml hauv 24 mus rau 36 teev, thiab cov ntshav ntawm triclobendazole thiab nws cov metabolites siab dua.Lub ncov tus nqi ntawm cov tshuaj yog 5 mus rau 20 npaug ntawm lwm yam benzimidazole anthelmintics, thiab tshem tawm ib nrab-lub neej yog hais txog 22 teev.Triclobendazole feem ntau oxidized nyob rau hauv yaj thiab nas rau sulfone thiab sulfoxide derivatives, uas khi rau albumin thiab pheej nyob rau hauv plasma rau ntau tshaj 7 hnub.Cov ntshav plasma siab thiab khi rau plasma albumin zoo li cuam tshuam nrog lub sijhawm ntev ntawm kev ua ntawm antifascioli.Tom qab 10 hnub ntawm kev tswj hwm tshuaj hauv cov yaj, kwv yees li 95% ntawm cov tshuaj tau tawm hauv cov quav, 2% yog tawm hauv cov zis, thiab tsawg dua 1% yog tawm hauv cov kua mis.
Kev Ua thiab Kev Siv
Benzimidazole anti-fasciola tshuaj.Nws yog tsuas yog siv rau kev tiv thaiv thiab kev kho mob ntawm Fasciola hepatica kab mob hauv nyuj thiab yaj.
Cov tshuaj tiv thaiv tsis zoo
Tsis muaj kev phiv tshwm sim thaum siv raws li kev siv thiab ntau npaum li cas
Cov kev ceev faj
(1) Ua tsis taus pa thaum lub sij hawm tsim mis nyuj.
(2) Nws muaj tshuaj lom heev rau cov ntses, thiab cov khoom seem ntawm cov tshuaj yuav tsum tsis txhob ua paug rau hauv dej.
(3) Cov neeg uas ua xua rau cov tshuaj yuav tsum tsis txhob sib cuag nrog daim tawv nqaij ncaj qha thiab nqus tau pa thaum siv, hnav hnab looj tes thaum noj tshuaj, thiab txwv tsis pub noj, haus thiab haus luam yeeb.
(4) Ntxuav tes tom qab thov
Lub sijhawm rho nyiaj
56 hnub rau nyuj thiab yaj
Cia
Khaws rau hauv qhov chaw qis dua 30 ℃.
Hebei Veyong kws tshuaj Co., Ltd, tau tsim nyob rau hauv 2002, nyob rau hauv Shijiazhuang City, Hebei xeev, Tuam Tshoj, ib sab ntawm lub peev Beijing.Nws yog ib lub tuam txhab loj GMP-certified veterinary tshuaj lag luam, nrog R & D, ntau lawm thiab muag khoom ntawm veterinary APIs, npaj, premixed pub thiab pub additives.Raws li Provincial Technical Center, Veyong tau tsim ib qho kev tsim kho tshiab R&D rau cov tshuaj kho tsiaj tshiab, thiab yog lub teb chaws paub txog kev tsim kho tshiab raws li kws kho tsiaj, muaj 65 tus kws tshaj lij.Veyong muaj ob lub hauv paus tsim khoom: Shijiazhuang thiab Ordos, uas lub hauv paus Shijiazhuang npog thaj tsam ntawm 78,706 m2, nrog 13 API khoom suav nrog Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, thiab 11 npaj cov kab ntau lawm suav nrog kev txhaj tshuaj, qhov ncauj tshuaj, , premix, bolus, tshuaj tua kab thiab tshuaj tua kab mob, ects.Veyong muab APIs, ntau tshaj 100 tus kheej-daim ntawv npaj, thiab OEM & ODM kev pabcuam.
Veyong tseem ceeb heev rau kev tswj hwm ntawm EHS (Environment, Health & Safety) system, thiab tau txais daim ntawv pov thawj ISO14001 thiab OHSAS18001.Veyong tau teev nyob rau hauv cov kev lag luam tawm tswv yim tawm tswv yim hauv Hebei Xeev thiab tuaj yeem ua kom cov khoom lag luam tas mus li.
Veyong tau tsim ua tiav kev tswj hwm zoo, tau txais daim ntawv pov thawj ISO9001, Tuam Tshoj GMP daim ntawv pov thawj, Australia APVMA GMP daim ntawv pov thawj, Ethiopia GMP daim ntawv pov thawj, Ivermectin CEP daim ntawv pov thawj, thiab dhau US FDA tshuaj xyuas.Veyong muaj pab pawg tshaj lij ntawm kev sau npe, kev muag khoom thiab kev pabcuam, peb lub tuam txhab tau txais kev cia siab thiab kev txhawb nqa los ntawm ntau tus neeg siv khoom los ntawm cov khoom lag luam zoo, kev muag khoom zoo thiab kev pabcuam tomqab muag, kev tswj xyuas thiab kev tshawb fawb.Veyong tau ua kev koom tes ntev nrog ntau lub tuam txhab kev lag luam tsiaj paub thoob ntiaj teb nrog cov khoom xa tawm mus rau Tebchaws Europe, South America, Middle East, Africa, Asia, thiab lwm yam ntau tshaj 60 lub teb chaws thiab cheeb tsam.
